Fighting Alzheimer's Disease
Fighting Alzheimer's Disease
Learn more about our research.
From Protons to Persons...
From Protons to Persons...
Explore our lab and methodology.
Our lab is committed to finding a cure for Alzheimer's Disease. Learn more about our ongoing projects and our past achievements.
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From Computational Chemists to Molecular Biologists, explore our multidisciplinary researchers.
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Explore our state of the art home at the Krembil Research Institute, University Health Network.
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Your brain is what makes you, you!

Here's what we're doing to protect it!

Our Search for A Cure

Our aim is to create a drug that will stop Alzheimer's in it's tracks. This process starts with identifying drug targets within the neurons of the brain, and ends with the synthesis and testing of a new chemical entitiy. This involves:
Computational Chemistry

Computational Chemistry

We use a range of computational chemistry techniques, including molecular modeling to quantum mechanical dynamics to predict what and how molecules will interact with Alzheimer's Disease Pathologies.
Synthetic Organic Chemistry

Synthetic Organic Chemistry

We take promising theoretical candidates and chemically synthesize and purify them. We make dozens of these potential drug-candidates every week.
Molecular Biology

Molecular Biology

Our biologists then test these compounds in a variety of assays to prove that they work and that they're safe to use.
Pharmacology

Pharmacology

Successful molecules then undergo a battery of pharmaceutical tests to observe how the body will digest and process these molecules. Drugs that show exceptional parameters here then go on to human trials.

Learn more about our current research projects.

Our Lab and Facilities

Our lab includes diverse experts and trainees from multiple scientific disciplines as well as comprehensive organic chemistry, cellular biology and spectroscopy facilities.

Why Alzheimer's Disease?

Alzheimer's disease has been one of medicine's most persistent and frustrating diseases. Over the past two decades, nearly 400 clinical trials tackling various aspects of Alzheimer's dementia have failed to show any significant effect. This leaves nearly 50 million patients with dementia with no treatment as they tackle a progressive deterioration of their memory, cognition and executive function. As our population gradually ages, estimates predict this number may rise to over 150 million in the next 30 years. Today, we are appreciating the complexity of Alzheimer's disease as a multi-factorial disorder of inflammation, protein misfolding, energy dysregulation and much more. Ultimately, the cure will likely have to be similarly multifaceted and attack the disease on multiple fronts. This is our goal, and this is what we are working relentlessly to find.
25000

New Cases (per year)

150

Million Patients with Alzheimer's by 2050.

10

Billion Dollars Expended per Year

564000

Currently living with Alzheimer's

Our Latest News

Catch up with some recent updates from our lab.

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